Synthesis of Lanthionine-Containing Peptides on Solid-Phase via an Orthogonal Protecting Group Strategy

Solid phase synthesis of peptides containing backbone-fluorinated amino acids.

Backbone-fluorinated amino acids exhibit unique conformational behaviour, and have potential utility as components of bioactive shape-controlled peptides. However, methods for the elaboration of backbone-fluorinated amino acids have thus far been limited to solution phase peptide coupling reactions. In this paper, protocols are developed that allow the successful manipulation of backbone-fluori...

Efficient solid-phase synthesis of fullero-peptides using Merrifield strategy.

Boc-protected l-fulleropyrrolidino-glutamic acid was readily prepared and employed for the synthesis of fullerene-containing peptides using the solid-phase Boc chemistry developed by Merrifield.

Solid-Phase Synthesis of Tetrahydropyridazinedione-Constrained Peptides

The design and solid-phase synthesis of tetrahydropyridazine-3,6-dione (Tpd) peptidomimetics derived from backbone-aminated peptides is reported. The described protocol features the synthesis of chiral α-hydrazino acids suitable for chemoselective incorporation into growing peptide chains. Acid-catalyzed cyclization to form the Tpd ring during cleavage affords the target peptidomimetics in good...

An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs.

A general problem that exists in the assembly of large and organized DNA structures from smaller fragments is secondary structure that blocks or prevents it. For example, it is common to assemble longer synthetic DNA and RNA fragments by ligation of smaller synthesized units, but blocking secondary structure can prevent the formation of the intended complex before enzymatic ligation can occur. ...

Solid-phase synthesis of peptides containing the CH2NH reduced bond surrogate.